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Miguelferig (conversa | contribucións)
303.609 edicións
Miguelferig (conversa | contribucións)
303.609 edicións
Liña 9: Liña 9:
* 1.A.1 Superfamilia dos [[Canais iónicos regulados por voltaxe]]
* 1.A.1 Superfamilia dos [[Canais iónicos regulados por voltaxe]]
* 1.A.2 [[Canal de K+ rectificador entrante]] animal
* 1.A.2 [[Canal de K+ rectificador entrante]] animal
* 1.A.3 [[Ryanodine-inositol-1,4,5-trisphosphate receptor Ca2+ channel]]
* 1.A.3 [[Canal de Ca2+ receptor de Ryanodine-inositol-1,4,5-trisfosfato]]
* 1.A.4 [[Transient receptor potential Ca2+ channel]]
* 1.A.4 [[Canal de Ca2+ de potencial receptor transitorio]]
* 1.A.5 [[Polycystin cation channel]]
* 1.A.5 [[Canal de catións de policistina]]
* 1.A.6 [[Epithelial Na+ channel]]
* 1.A.6 [[Canal de Na+ epitelial]]
* 1.A.7 [[ATP-gated cation channel]]
* 1.A.7 [[Canal de catións regulado por ATP]]
* 1.A.8 [[Major intrinsic protein]]
* 1.A.8 [[Proteín a intrínseca maior]]
* 1.A.9 [[Canal iónico regulado por ligando]] de [[receptor de neurotransmisores|receptores de neurotransmisores]]
* 1.A.9 [[Ligand-gated ion channel]] of [[neurotransmitter receptor]]s
* 1.A.10 [[Canal iónico regulado por glutmato]] de receptores de neurotransmisores
* 1.A.10 [[Glutamate-gated ion channel]] of [[neurotransmitter receptor]]s
* 1.A.11 [[Chloride channel]]
* 1.A.11 [[Canal de cloruro]]
* 1.A.12 [[Organellar chloride channel]]
* 1.A.12 [[Canal de cloruro organular]]
* 1.A.13 [[Epithelial chloride channel]]
* 1.A.13 [[Canal de cloruro epitelial]]
* 1.A.14 [[Nonselective cation channel-1]]
* 1.A.14 [[canal de catións non selectivo 1]]
* 1.A.15 [[Nonselective cation channel-2]]
* 1.A.15 [[Canal de catións non selectivo 2]]
* 1.A.16 [[Canal de Ca2+, selectivo de catións activado por estiramento de lévedos]]
* 1.A.16 [[Yeast stretch-activated, cation-selective, Ca2+ channel]]
* 1.A.17 [[Canal de solutos da membrana externa dos cloroplastos]]
* 1.A.17 [[Chloroplast outer-membrane solute channel]]
* 1.A.18 [[Formador do canal de anións da membrana do cloroplasto]]
* 1.A.18 [[Chloroplast membrane anion-channel-former]]
* 1.A.19 [[Influenza virus matrix-2 channel]]
* 1.A.19 [[canal da matriz 2 do virus da influenza]]
* 1.A.20 [[gp91phox phagocyte NADPH-oxidase-associated cyt b558 H+-channel]]
* 1.A.20 [[canal de H+ do cyt b558 asociado á gp91phox fagocito NADPH-oxidase]]
* 1.A.21 [[Apoptosis regulator]]
* 1.A.21 [[Regulador da apoptose]]
* 1.A.22 [[Canal iónico mecanosensible de gran condutancia]]
* 1.A.22 [[Large-conductance mechanosensitive ion channel]]
* 1.A.23 [[Canal iónico mecanosensible de pequena condutancia]]
* 1.A.23 [[Small-conductance mechanosensitive ion channel]]
* 1.A.24 [[Gap-junction]]-forming [[connexin]]
* 1.A.24 [[Conexina]] formadora de [[unión comunicante|unións comunicantes]]
* 1.A.25 [[Gap-junction]]-forming [[innexin]]
* 1.A.25 [[Innexina]] formadora de unións comunicantes
* 1.A.26 Plant [[plasmodesmata]]
* 1.A.26 [[Plasmodesmo]]s de plantas
* 1.A.27 [[Phospholemman]]
* 1.A.27 [[Fosfolemman]]
* 1.A.28 [[Urea transporter]] (channel)
* 1.A.28 [[Transportador de urea]] (canal)
* 1.A.29 [[Urea/amide channel]]
* 1.A.29 [[Canal de urea/amida]]
* 1.A.30 [[H+- or Na+-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily]]
* 1.A.30 [[superfamilia do enerxizador do transporte MotAB motor flaxelar/ExbBD da membrana externa bacteriano translocador de H+- ou Na+]]
* 1.A.31 [[Annexin]]
* 1.A.31 [[Anexina]]
* 1.A.32 [[Type B influenza virus NB channel]]
* 1.A.32 [[Canal NB do virus da influenza Tipo B]]
* 1.A.33 Cation-channel-forming [[heat-shock protein 70]]
* 1.A.33 [[Proteína de shock térmico 70]] formadora de canais de catións
* 1.A.34 [[Envelope virus E1 channel]]
* 1.A.34 [[Canal E1 do virus Envelope]]
* 1.A.35 [[Metal-ion transporter]] (channel)
* 1.A.35 [[Transportador de ións metálicos]] (canal)
* 1.A.36 [[Intracellular chloride channel]]
* 1.A.36 [[Canal de cloruro intracelular]]


====1.B [[β-Barrel]] porins====
====1.B [[β-Barrel]] porins====

Revisión como estaba o 18 de decembro de 2015 ás 22:51

A Transporter Classification Database ou TCDB (Base de Datos de Clasificación de Transportadores) é un sistema de clasificación aprobado pola International Union of Biochemistry and Molecular Biology (IUBMB) para as proteínas transportadoras de membrana incluíndo os canais iónicos.[1] Este sistema de clasificación foi deseñado para que fose análogo ao sistema do número EC para a clasificación de encimas, pero utiliza tamén información filoxenética.

Clasificación

Velaquí o nivelsuperior de clasificación e algúns exemplos de proteínas con estrutura tridimensional coñecida:

1. Canais/Poros

1.A Canais de tipo α

1.B β-Barrel porins

1.C Pore-forming toxins (proteins and peptides)

1.D Non-ribosomally synthesized channels

1.E Holins

1.F Vesicle fusion pores

1.G Viral fusion pores

1.H Paracellular channels

1.I Membrane-bound channels

Ungrouped

2. Electrochemical Potential-driven Transporters

2.A Porters (uniporters, symporters, antiporters)

2.B Nonribosomally synthesized porters

2.C Ion-gradient-driven energizers

Ungrouped

  • Mitochondrial carrier proteins[10]
  • Major Facilitator Superfamily (Glycerol-3-phosphate transporter, Lactose permease, and Multidrug transporter EmrD)[11]
  • Resistance-nodulation-cell division (multidrug efflux transporter AcrB, see multidrug resistance)[12]
  • Dicarboxylate/amino acid:cation symporter (proton glutamate symporter)[13]
  • Monovalent cation/proton antiporter (Sodium/proton antiporter 1 NhaA)[14]
  • Neurotransmitter sodium symporter[15]
  • Ammonia transporters[16]
  • Drug/Metabolite Transporter (small multidrug resistance transporter EmrE - the structures are retracted as erroneous)[17]

3. Primary Active Transporters

3.A. P-P-bond hydrolysis-driven transporters

3.B Decarboxylation-driven transporters

3.C Methyltransfer-driven transporters

3.D. Oxidoreduction-driven transporters

3.E. Light absorption-driven transporters

Ungrouped Electrochemical potential-driven transporters

  • Proton or sodium translocating F-type and V-type ATPases[29]

4. Group Translocators

4.A Phosphotransfer-driven group translocators

4.B Nicotinamide ribonucleoside uptake transporters

4.C Acyl CoA ligase-coupled transporters

5. Transport Electron Carriers

5.A Transmembrane 2-electron transfer carriers

5.B Transmembrane 1-electron transfer carriers

Non agrupados

  • Disulfide bond formation protein B (DsbB)[30]

6. Unused

Reserved for future expansion

7. Non usados

Reserved for future expansion

8. Accessory Factors Involved in Transport

8.A Auxiliary transport proteins

8.B Ribosomally synthesized protein/peptide toxins that target channels and carriers

8.C Non-ribosomally synthesized toxins that target channels and carriers

9. Incompletely Characterized Transport Systems

9.A Recognized transporters of unknown biochemical mechanism

9.B Putative transport proteins

9.C Functionally characterized transporters lacking identified sequences

Exemplos

Notas

  1. ↑ Saier MH, Yen MR, Noto K, Tamang DG, Elkan C (January 2009). "The Transporter Classification Database: recent advances". Nucleic Acids Res. 37 (Database issue): D274–8. PMC 2686586. PMID 19022853. doi:10.1093/nar/gkn862.
  2. ↑ http://opm.phar.umich.edu/families.php?superfamily=8
  3. ↑ http://opm.phar.umich.edu/families.php?superfamily=12
  4. ↑ http://opm.phar.umich.edu/families.php?superfamily=11
  5. ↑ http://opm.phar.umich.edu/families.php?superfamily=72
  6. ↑ http://opm.phar.umich.edu/families.php?superfamily=14
  7. ↑ http://opm.phar.umich.edu/families.php?superfamily=7
  8. ↑ http://opm.phar.umich.edu/families.php?superfamily=10
  9. ↑ http://opm.phar.umich.edu/families.php?superfamily=188
  10. ↑ http://opm.phar.umich.edu/families.php?superfamily=21
  11. ↑ http://opm.phar.umich.edu/families.php?superfamily=15
  12. ↑ http://opm.phar.umich.edu/families.php?superfamily=16
  13. ↑ http://opm.phar.umich.edu/families.php?superfamily=20
  14. ↑ http://opm.phar.umich.edu/families.php?superfamily=66
  15. ↑ http://opm.phar.umich.edu/families.php?superfamily=67
  16. ↑ http://opm.phar.umich.edu/families.php?superfamily=13
  17. ↑ http://opm.phar.umich.edu/families.php?superfamily=77
  18. ↑ http://opm.phar.umich.edu/families.php?superfamily=22
  19. ↑ http://opm.phar.umich.edu/families.php?superfamily=70
  20. ↑ http://opm.phar.umich.edu/families.php?superfamily=17
  21. ↑ http://opm.phar.umich.edu/families.php?superfamily=18
  22. ↑ http://opm.phar.umich.edu/families.php?superfamily=198
  23. ↑ http://opm.phar.umich.edu/families.php?superfamily=19
  24. ↑ http://opm.phar.umich.edu/families.php?superfamily=3
  25. ↑ http://opm.phar.umich.edu/families.php?superfamily=4
  26. ↑ http://opm.phar.umich.edu/families.php?superfamily=6
  27. ↑ http://opm.phar.umich.edu/families.php?superfamily=2
  28. ↑ http://opm.phar.umich.edu/families.php?superfamily=1
  29. ↑ http://opm.phar.umich.edu/families.php?superfamily=5
  30. ↑ http://opm.phar.umich.edu/protein.php?search=2hi7

Véxase tamén

Ligazóns externas

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