BCL6

BCL6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M
Dynodwyr
Cyfenwau	BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor
Dynodwyr allanol	OMIM: 109565 HomoloGene: 7640 GeneCards: BCL6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • intronic transcription regulatory region sequence-specific DNA binding • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • chromatin DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • replication fork • cnewyllyn cell • nucleoplasm • Golgi apparatus Prosesau biolegol • regulation of germinal center formation • positive regulation of histone deacetylation • negative regulation of T-helper 2 cell differentiation • GO:0034613 protein localization • negative regulation of mast cell cytokine production • GO:0009373 regulation of transcription, DNA-templated • proses y system imiwnedd • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of cell differentiation • germinal center formation • negative regulation of Rho protein signal transduction • negative regulation of isotype switching to IgE isotypes • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • type 2 immune response • cellular response to DNA damage stimulus • negative regulation of cell-matrix adhesion • regulation of cell population proliferation • positive regulation of B cell proliferation • negative regulation of cell growth • Rho protein signal transduction • GO:0000767 cell morphogenesis • spermatogenesis • regulation of memory T cell differentiation • positive regulation of neuron differentiation • regulation of inflammatory response • regulation of immune response • positive regulation of apoptotic process • negative regulation of type 2 immune response • negative regulation of B cell apoptotic process • B cell differentiation • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • actin cytoskeleton organization • negative regulation of cell population proliferation • negative regulation of Notch signaling pathway • erythrocyte development • negative regulation of cellular senescence • regulation of apoptotic process • negative regulation of mitotic cell cycle DNA replication • positive regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	604	n/a
Ensembl	ENSG00000113916	n/a
UniProt	P41182	n/a
RefSeq (mRNA)	NM_001130845 NM_001134738 NM_001706 NM_138931	n/a
RefSeq (protein)	NP_001124317 NP_001128210 NP_001697	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL6 yw BCL6 a elwir hefyd yn B-cell lymphoma 6 protein a B-cell CLL/lymphoma 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q27.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL6.

• "Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. ". Fertil Steril. 2017. PMID 29126613.
• "Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response. ". Cancer Sci. 2017. PMID 28544233.
• "BCL6 mediates the effects of Gastrodin on promoting M2-like macrophage polarization and protecting against oxidative stress-induced apoptosis and cell death in macrophages. ". Biochem Biophys Res Commun. 2017. PMID 28315684.
• "BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. ". Cancer Discov. 2017. PMID 28232365.
• "Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.". Biochem Biophys Res Commun. 2017. PMID 27856253.