CSRP2-binding protein

KAT14
Identifiers
Aliases	KAT14, ATAC2, CRP2BP, PRO1194, dJ717M23.1, CSRP2BP, lysine acetyltransferase 14
External IDs	OMIM: 617501; MGI: 1917264; GeneCards: KAT14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CU8
Gene location (Human)
Chr.	Chromosome 20 (human)
End	18,188,387 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	144,249,596 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; skin of arm; ; cardiac muscle tissue of right atrium; ; gonad; ; myocardium of left ventricle; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle; ; testicle;
	Top expressed in
	primary oocyte; ; zygote; ; internal carotid artery; ; external carotid artery; ; secondary oocyte; ; genital tubercle; ; hand; ; otolith organ; ; utricle; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	LIM domain binding; protein binding; histone acetyltransferase activity;
Cellular component	cytoplasm; nucleus;
Biological process	G2/M transition of mitotic cell cycle; histone acetylation; histone H3 acetylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57325
	228714
	ENSG00000149474
	ENSMUSG00000027425
	Q9H8E8
	Q8CID0
	NM_020536; NM_177926
	NM_001166640; NM_181417
	NP_065397; NP_001371121
	NP_001160112; NP_852082
	Wikidata
View/Edit Human	View/Edit Mouse

CSRP2-binding protein is a protein that in humans is encoded by the KAT14 gene (previously CSRP2BP).^[5] This function is part of the ADA2A-containing complex (ATAC), a protein complex that acts as an histone acetyltransferase for the histones H3 and H4.^[6] Also called lysine acetyltransferase 14 (KAT14), CSRP2BP itself has weak histone acetyltransferase activity towards H4.^[6]

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149474 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027425 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CSRP2 binding protein". Retrieved 2011-09-20.
1 2 "Cysteine-rich protein 2-binding protein". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

External links

Human CSRP2BP genome location and CSRP2BP gene details page in the UCSC Genome Browser.

Weiskirchen R, Gressner AM (August 2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochemical and Biophysical Research Communications. 274 (3): 655–663. Bibcode:2000BBRC..274..655W. doi:10.1006/bbrc.2000.3187. PMID 10924333.
Wang YL, Faiola F, Xu M, Pan S, Martinez E (December 2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". The Journal of Biological Chemistry. 283 (49): 33808–33815. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, et al. (March 2009). "The double-histone-acetyltransferase complex ATAC is essential for mammalian development". Molecular and Cellular Biology. 29 (5): 1176–1188. doi:10.1128/MCB.01599-08. PMC 2643826. PMID 19103755.
Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, et al. (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–959. doi:10.1038/mp.2010.107. PMID 21079607. S2CID 15188506.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149474 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027425 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CSRP2 binding protein". Retrieved 2011-09-20.

[uniprot-6] 1 2 "Cysteine-rich protein 2-binding protein". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

[1]

[2]

[3]

[4]

[5]

[6]

References

External links

Further reading