ELP2

ELP2
معین‌کننده‌ها
نام‌های دیگر	ELP2, SHINC-2, STATIP1, StIP, elongator acetyltransferase complex subunit 2, MRT58
شناسه‌های بیرونی	OMIM: 616054; MGI: 1889642; HomoloGene: 6019; GeneCards: ELP2; OMA:ELP2 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۱۸ (انسان)
پایان	36,180,557 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۸ (موش)
پایان	24,772,564 bp
الگوی گسترش RNA
	بیشترین بیان در
	left ovary; ; right ovary; ; skin of abdomen; ; ganglionic eminence; ; skin of leg; ; epithelium of colon; ; right uterine tube; ; body of pancreas;
	بیشترین بیان در
	otic placode; ; facial motor nucleus; ; fossa;
	داده‌های بیشتر بیان
	ناموجود
هستی‌شناسی ژن
عملکرد ملکولی	RNA polymerase II complex binding; protein kinase binding;
ترکیبات سلولی	histone acetyltransferase complex; transcription elongation factor complex; هسته سلول; سیتوپلاسم; سیتوزول; elongator holoenzyme complex;
فرایند زیستی	regulation of transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of receptor signaling pathway via JAK-STAT; tRNA wobble uridine modification;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	55250
	58523
	ENSG00000134759
	ENSMUSG00000024271
	Q6IA86
	Q91WG4
NM_001242875; NM_001242876; NM_001242877; NM_001242878; NM_001242879;
	NM_018255; NM_001324465; NM_001324466; NM_001324467; NM_001324468; NM_001324469
	NM_021448; NM_001360909
NP_001229804; NP_001229805; NP_001229806; NP_001229807; NP_001229808;
	NP_001311394; NP_001311395; NP_001311396; NP_001311397; NP_060725
	NP_067423; NP_001347838
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۲ کمپلکس النگاتور پروتئینی است که در انسان توسط ژن ELP2 کدگذاری می‌شود.^[۵]^[۶]^[۷]

فعل و انفعالات

مشخص شده‌است که این پروئتین با STAT3 ^[۶] و Janus kinase 1 تعامل پروتئین-پروتئین دارد.^[۶]

منابع

1 2 3 GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
1 2 3 Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
↑ "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

جهت مطالعه

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11714725-5] Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.

[pmid10954736-6] 1 2 3 Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.

[entrez-7] "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

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