STOML2

STOML2
معین‌کننده‌ها
نام‌های دیگر	STOML2, SLP-2, HSPC108, stomatin like 2
شناسه‌های بیرونی	OMIM: 608292; MGI: 1913842; HomoloGene: 8389; GeneCards: STOML2; OMA:STOML2 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۹ (انسان)
پایان	35,103,195 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	43,031,710 bp
الگوی گسترش RNA
	بیشترین بیان در
	apex of heart; ; mucosa of transverse colon; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex;
	بیشترین بیان در
	epiblast; ; ventricular zone; ; tail of embryo;
	داده‌های بیشتر بیان
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	cardiolipin binding; پیوند پروتئینی; GTPase binding; signaling receptor binding; lipid binding;
ترکیبات سلولی	سیتوپلاسم; membrane; mitochondrial intermembrane space; پوسته یاخته; T cell receptor complex; میتوکندری; immunological synapse; actin cytoskeleton; لیپید رفت; COP9 signalosome; extrinsic component of plasma membrane; اسکلت سلولی; mitochondrial inner membrane;
فرایند زیستی	CD4-positive, alpha-beta T cell activation; mitochondrial ATP synthesis coupled proton transport; mitochondrion organization; cellular calcium ion homeostasis; positive regulation of mitochondrial DNA replication; mitochondrial protein processing; lipid localization; protein complex oligomerization; stress-induced mitochondrial fusion; positive regulation of cardiolipin metabolic process; positive regulation of mitochondrial membrane potential; T cell receptor signaling pathway; interleukin-2 production; mitochondrial calcium ion transmembrane transport;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	30968
	66592
	ENSG00000165283
	ENSMUSG00000028455
	Q9UJZ1
	Q99JB2
	NM_013442; NM_001287031; NM_001287032; NM_001287033
	NM_023231
	NP_001273960; NP_001273961; NP_001273962; NP_038470
	NP_075720
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۲ شبه استوماتین پروتئینی است که در انسان توسط ژن STOML2 کدگذاری می‌شود.^[۵]^[۶]^[۷]

منابع

1 2 3 GRCh38: Ensembl release 89: ENSG00000165283 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028455 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang Y, Morrow JS (Apr 2000). "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues". J Biol Chem. 275 (11): 8062–71. doi:10.1074/jbc.275.11.8062. PMID 10713127.
↑ Hajek P, Chomyn A, Attardi G (Feb 2007). "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2" (PDF). J Biol Chem. 282 (8): 5670–81. doi:10.1074/jbc.M608168200. PMID 17121834.
↑ "Entrez Gene: STOML2 stomatin (EPB72)-like 2".

جهت مطالعه

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Owczarek CM, Treutlein HR, Portbury KJ, et al. (2001). "A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1". Cytogenet. Cell Genet. 92 (3–4): 196–203. doi:10.1159/000056902. PMID 11435687. S2CID 19349691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Zhang L, Ding F, Cao W, et al. (2006). "Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma". Clin. Cancer Res. 12 (5): 1639–46. doi:10.1158/1078-0432.CCR-05-1858. PMID 16533792.
John JP, Anrather D, Pollak A, Lubec G (2006). "Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure". Proteins. 64 (2): 543–51. doi:10.1002/prot.20987. PMID 16671055. S2CID 24782924.
Cui Z, Zhang L, Hua Z, et al. (2007). "Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma". Oncol. Rep. 17 (4): 829–33. doi:10.3892/or.17.4.829. PMID 17342323.
Cao W, Zhang B, Liu Y, et al. (2007). "High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival". Am. J. Clin. Pathol. 128 (3): 430–6. doi:10.1309/C6X54HRB580EP2NQ. PMID 17709317.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165283 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028455 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_10713127-5] Wang Y, Morrow JS (Apr 2000). "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues". J Biol Chem. 275 (11): 8062–71. doi:10.1074/jbc.275.11.8062. PMID 10713127.

[pmid_17121834-6] Hajek P, Chomyn A, Attardi G (Feb 2007). "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2" (PDF). J Biol Chem. 282 (8): 5670–81. doi:10.1074/jbc.M608168200. PMID 17121834.

[entrez-7] "Entrez Gene: STOML2 stomatin (EPB72)-like 2".

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