IRF7

IRF7
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2O61 ;
Identificadores
Nomenclatura	Outros nomes IRF7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, factor regulador do interferón 7, IRF-7 ;
Símbolos	IRF7 (HGNC: 6122) IRF7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, IRF-7
Identificadores; externos	OMIM: 605047 ; MGI: 1859212 ; HomoloGene: 128624 ; EBI: IRF7 ; GeneCards: Xene IRF7 ; UniProt: IRF7 ;
Locus	Cr. 11 p15.5
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
3665	54123
Ensembl
Véxase HS	Véxase MM
UniProt
Q92985	P70434
RefSeq; (ARNm)
NM_001572	NM_001252600
RefSeq; (proteína) NCBI
NP_001563	NP_001239529
Localización (UCSC)
Cr. 11:; 0.61 – 0.62 Mb	Cr. 7:; 140.84 – 140.85 Mb
PubMed (Busca)
3665 ;	54123

O factor regulador do interferón 7 ou IRF7 é un membro da familia do factor regulador do interferón de factores de transcición.

Función

O xene IRF7 codifica o factor regulador do interferón 7, un membro da familia de factores de tanscrición reguladores do interferón (IRF). IRF7 xoga un papel na activación transcricional dos xenes celulares inducibles por interferón, incluíndo os xenes de interferóns tipo I. En particular, IRF7 regula moitos xenes do interferón-alfa.^[1] A expresión constitutiva de IRF7 está en gran medida restrinxida ao tecido linfoide, principalmente a células dendríticas plasmacitoides, mentres que IRF7 é inducible en moitos tecidos. Identificáronse múltiples variantes de transcrición de IRF7, aínda que as consecuencias funcionais destas non foron aínda establecidos.^[2]

A vía do IRF7 está silenciada nalgunhas liñas de células de cancro de mama metastásico, que poden axudar ás células a vitar a resposta inmune do hóspede.^[3] Restaurar o IRF7 nestas liñas celulares reducía as metástases e incrementaba o tempo de supervivencia do hóspede en modelos animais.

O xene IRF7 e o seu produto viuse que eran defectivos nun paciente estudado con susceptibilidade grave á gripe H1N1, mentres que a susceptibilidade a outras doenzas virais como o CMV, RSV e parainluenza non estaba afectada.^[4]

Interaccións

IRF7 presenta interaccións con IRF3.^[5] Tamén interacciona coa proteína que interacciona co receptor de aril hidrocarburos (AIP), que é un regulador negativo para a vía antiviral.^[6]

Notas

↑ Marié I, Durbin JE, Levy DE (novembro de 1998). "Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7". The EMBO Journal 17 (22): 6660–9. PMC 1171011. PMID 9822609. doi:10.1093/emboj/17.22.6660.
↑ "Entrez Gene: IRF7 interferon regulatory factor 7".
↑ Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine 18 (8): 1224–1231. PMID 22820642. doi:10.1038/nm.2830.
↑ Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL (abril de 2015). "Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency". Science 348 (6233): 448–53. PMC 4431581. PMID 25814066. doi:10.1126/science.aaa1578.
↑ Au WC, Yeow WS, Pitha PM (febreiro de 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. PMID 11162841. doi:10.1006/viro.2000.0782.
↑ Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW (xuño de 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon". The Journal of Biological Chemistry 290 (23): 14729–39. PMC 4505538. PMID 25911105. doi:10.1074/jbc.M114.633065.

Véxase tamén

Bibliografía

Ning S, Pagano JS, Barber GN (setembro de 2011). "IRF7: activation, regulation, modification and function". Genes and Immunity 12 (6): 399–414. PMC 4437765. PMID 21490621. doi:10.1038/gene.2011.21.
Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. PMID 9865487. doi:10.1016/S0300-9084(99)80018-2.
Zhang L, Pagano JS (xaneiro de 2002). "Structure and function of IRF-7". Journal of Interferon & Cytokine Research 22 (1): 95–101. PMID 11846980. doi:10.1089/107999002753452700.
Zhang L, Pagano JS (outubro de 1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Molecular and Cellular Biology 17 (10): 5748–57. PMC 232423. PMID 9315633. doi:10.1128/MCB.17.10.5748.
Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T (marzo de 1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Molecular Cell 1 (4): 507–18. PMID 9660935. doi:10.1016/S1097-2765(00)80051-9.
Au WC, Moore PA, LaFleur DW, Tombal B, Pitha PM (outubro de 1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". The Journal of Biological Chemistry 273 (44): 29210–7. PMID 9786932. doi:10.1074/jbc.273.44.29210.
Lu R, Au WC, Yeow WS, Hageman N, Pitha PM (outubro de 2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation". The Journal of Biological Chemistry 275 (41): 31805–12. PMID 10924517. doi:10.1074/jbc.M005288200.
Paris MJ, Williams BR (outubro de 2000). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202. PMID 11031102. doi:10.1006/geno.2000.6339.
Marié I, Smith E, Prakash A, Levy DE (decembro de 2000). "Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain". Molecular and Cellular Biology 20 (23): 8803–14. PMC 86519. PMID 11073981. doi:10.1128/MCB.20.23.8803-8814.2000.
Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE (marzo de 2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". The Journal of Biological Chemistry 276 (12): 8951–7. PMID 11124948. doi:10.1074/jbc.M008717200.
Au WC, Yeow WS, Pitha PM (febreiro de 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. PMID 11162841. doi:10.1006/viro.2000.0782.
Lu R, Moore PA, Pitha PM (maio de 2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". The Journal of Biological Chemistry 277 (19): 16592–8. PMID 11877397. doi:10.1074/jbc.M111440200.
Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A (marzo de 2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". Journal of Molecular Biology 316 (5): 1009–22. PMID 11884139. doi:10.1006/jmbi.2001.5401.
Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I (decembro de 2002). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". The Journal of Biological Chemistry 277 (51): 49417–21. PMID 12374802. doi:10.1074/jbc.M207484200.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (febreiro de 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine 9 (2): 191–7. PMID 12539042. doi:10.1038/nm822.
Yang H, Lin CH, Ma G, Baffi MO, Wathelet MG (maio de 2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". The Journal of Biological Chemistry 278 (18): 15495–504. PMID 12604599. doi:10.1074/jbc.M212940200.
Ning S, Hahn AM, Huye LE, Pagano JS (setembro de 2003). "Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit". Journal of Virology 77 (17): 9359–68. PMC 187426. PMID 12915551. doi:10.1128/JVI.77.17.9359-9368.2003.
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT (outubro de 2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". The Journal of Experimental Medicine 198 (7): 1043–55. PMC 2194210. PMID 14517278. doi:10.1084/jem.20031023.
Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL (febreiro de 2004). "The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes". Journal of Virology 78 (4): 1675–84. PMC 369457. PMID 14747533. doi:10.1128/JVI.78.4.1675-1684.2004.

Ligazóns externas

IRF7 protein, human Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.

Este artigo incorpora textos da Biblioteca Nacional de Medicina dos Estados Unidos, que están en dominio público.

[pmid9822609-1] Marié I, Durbin JE, Levy DE (novembro de 1998). "Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7". The EMBO Journal 17 (22): 6660–9. PMC 1171011. PMID 9822609. doi:10.1093/emboj/17.22.6660.

[entrez-2] "Entrez Gene: IRF7 interferon regulatory factor 7".

[3] Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine 18 (8): 1224–1231. PMID 22820642. doi:10.1038/nm.2830.

[4] Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL (abril de 2015). "Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency". Science 348 (6233): 448–53. PMC 4431581. PMID 25814066. doi:10.1126/science.aaa1578.

[pmid11162841-5] Au WC, Yeow WS, Pitha PM (febreiro de 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. PMID 11162841. doi:10.1006/viro.2000.0782.

[6] Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW (xuño de 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon". The Journal of Biological Chemistry 290 (23): 14729–39. PMC 4505538. PMID 25911105. doi:10.1074/jbc.M114.633065.

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