Globoside

Globoside
Globoside
structural class of chemical entities (en)
Bayanai
Ƙaramin ɓangare na	glycosphingolipid (en)
Bangare na	globoside metabolic process (en) , globoside biosynthetic process (en) da globoside biosynthetic process via lactosylceramide (en)

Sphingosine

Globosides (wanda kuma aka fi sani da glycosphingolipid na globo-series) wani rukuni ne na glycosphingoslipid ^[1] tare da kwayoyin sukari uku zuwa tara a matsayin sarkar gefe (ko R rukuni) na ceramide. Shukurin yawanci haɗuwa ne na N-acetylgalactosamine, D-glucose ko D-galactose. Ɗaya daga cikin halaye na globosides shine cewa "core" sukari ya ƙunshi Glucose-Galactose-Galactosis (Ceramide-βGlc4-1βGal4-1αGal), kamar yadda yake game da mafi mahimmancin globoside, globotriaosylceramide (Gb3), wanda aka fi sani da pk-antigen.^[2] Wani muhimmin hali na globosides shine cewa suna da tsaka-tsaki a pH 7, saboda yawanci ba su dauke da Neuraminic acid ba, sukari tare da ƙungiyar carboxy acidic. Koyaya, wasu globosides tare da tsarin Cer-Glc-Gal-Gal suna ƙunshe da neuraminic acid, misali glycosphingolipid "SSEA-4-antigen".

Ana kuma iya raba sarkar gefe ta hanyar galactosidases da glucosidases. Rashin α-galactosidase A yana haifar da Cutar Fabry, cuta ce ta gado wacce ke nuna tarin globoside globotriaosylceramide.^[3]

Globoside-4 (Gb4)

Globoside 4 (Gb4) an san shi da mai karɓa parvovirus B19, saboda abubuwan lura cewa B19V yana ɗaurewa zuwa chromatogram mai laushi na tsari. Koyaya, ɗaurewa a farfajiya ba ta dace da kwayar cuta ba, wanda ya haifar da muhawara game da ko GB4 shine dalilin kamuwa da cuta.^[4] Ƙarin bincike ta amfani da fasahar Knockout Cell Line ya nuna cewa kodayake GB4 ba shi da mai karɓar shigarwa kai tsaye don B19V, yana taka rawar da ya taka bayan shigarwa a cikin kamuwa da cuta.^[5]

Globoside 4 (Gb4) wani nau'i ne na SSEA, takamaiman antigen na embryonic, wanda yake a cikin ci gaban salula da kyallen da ke cikin kumburi ba tare da an san tsarin Gb4 ba. Koyaya binciken ya nuna Gb4 kai tsaye yana kunna mai karɓar haɓakar epidermal ta hanyar siginar ERK. Lokacin da aka rage glycosphingolipid (GSL) a cikin gwaji an kuma hana siginar ERK daga mai karɓar tyrosine kinase. An sake kunna ERK tare da kara da Gb4 kuma daga nan gaba ya ƙara yaɗuwar ƙwayoyin ciwon daji kuma ya buɗe yiwuwar gwada Gb4 don ƙarin karatu akan magungunan da za su iya yin niyya ga ƙwayoyin cutar kansa.^[6]

Globoside-5 (Gb5)

Globoside-5 kuma an san shi da takamaiman antigen embryonic 3.

Manazarta

↑ Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, et al. (April 2009). "Update of the LIPID MAPS comprehensive classification system for lipids". Journal of Lipid Research. 50 (Suppl): S9-14. doi:10.1194/jlr.r800095-jlr200. PMC 2674711. PMID 19098281.
↑ "Globotriaosylceramide". Lipid Maps.
↑ Germain DP (2002). "[Fabry's disease (alpha-galactosidase-A deficiency): physiopathology, clinical signs, and genetic aspects]". Journal de la Société de Biologie. 196 (2): 161–173. doi:10.1051/jbio/2002196020161. PMID 12360745. S2CID 87466647.
↑ Nasir W, Nilsson J, Olofsson S, Bally M, Rydell GE (May 2014). "Parvovirus B19 VLP recognizes globoside in supported lipid bilayers". Virology. 456-457: 364–369. doi:10.1016/j.virol.2014.04.004. PMID 24889255.
↑ Bieri J, Ros C (October 2019). "Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection". Journal of Virology. 93 (20). doi:10.1128/JVI.00972-19. PMC 6798098. PMID 31341051.
↑ Park SY, Kwak CY, Shayman JA, Kim JH (July 2012). "Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor". Biochimica et Biophysica Acta (BBA) - General Subjects. 1820 (7): 1141–1148. doi:10.1016/j.bbagen.2012.04.008. PMC 3645941. PMID 22542783.

Haɗin waje

Media related to Globósido at Wikimedia Commons
Globosidesa cikin ɗakin karatu na kasa na AmurkaTakaddun Magunguna (MeSH)

[1] Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, et al. (April 2009). "Update of the LIPID MAPS comprehensive classification system for lipids". Journal of Lipid Research. 50 (Suppl): S9-14. doi:10.1194/jlr.r800095-jlr200. PMC 2674711. PMID 19098281.

[2] "Globotriaosylceramide". Lipid Maps.

[3] Germain DP (2002). "[Fabry's disease (alpha-galactosidase-A deficiency): physiopathology, clinical signs, and genetic aspects]". Journal de la Société de Biologie. 196 (2): 161–173. doi:10.1051/jbio/2002196020161. PMID 12360745. S2CID 87466647.

[4] Nasir W, Nilsson J, Olofsson S, Bally M, Rydell GE (May 2014). "Parvovirus B19 VLP recognizes globoside in supported lipid bilayers". Virology. 456-457: 364–369. doi:10.1016/j.virol.2014.04.004. PMID 24889255.

[5] Bieri J, Ros C (October 2019). "Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection". Journal of Virology. 93 (20). doi:10.1128/JVI.00972-19. PMC 6798098. PMID 31341051.

[6] Park SY, Kwak CY, Shayman JA, Kim JH (July 2012). "Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor". Biochimica et Biophysica Acta (BBA) - General Subjects. 1820 (7): 1141–1148. doi:10.1016/j.bbagen.2012.04.008. PMC 3645941. PMID 22542783.

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