Timothy Ray Brown

Timothy Ray Brown
Rayuwa
Haihuwa	Seattle, 11 ga Maris, 1966
ƙasa	Tarayyar Amurka
Mazauni	Berlin
Mutuwa	Palm Springs (mul) , 29 Satumba 2020
Yanayin mutuwa	Sababi na ainihi (acute myeloid leukemia (en) )
Karatu
Harsuna	Turanci Jamusanci
Sana'a
Sana'a	mai aikin fassara
IMDb	nm4474519

Timothy Ray Brown (Maris 11, 1966  – Satumba 29, 2020) ɗan Amurka ne wanda aka yi la'akari da shi a matsayin mutum na farko da aka warkar da shi daga cutar HIV/AIDS . ^{[1] [2]} An yi wa Brown lakabi da "Majinyacin Berlin" a taron 2008 kan cutar Retroviruses da Infections Opportunistic, inda aka fara sanar da maganinsa, domin a ɓoye sunansa. Ya zaɓi ya fito a shekarar 2010. "Ban so in zama mutum ɗaya tilo da aka warkar da shi ba," in ji shi. "Ina so in yi duk abin da zan iya don ganin an yi maganin cutar. Mataki na farko da na ɗauka shine bayyana sunana da hotona ga jama'a." ^{[3] [1] [4]}

An haifi Timothy Ray Brown a Seattle, Washington, a ranar 11 ga Maris, 1966, kuma mahaifiyarsa Sharon, wacce ba ta da aure, ta girma a yankin, wacce ke aiki a sashen 'yan sanda na King County . Ya yi tafiya a faɗin Turai tun yana ƙarami kuma an gano yana ɗauke da cutar kanjamau a shekarar 1995 yayin da yake karatu a Berlin . ^[3] A shekara ta 2006, an gano yana da cutar sankarar jini mai tsanani ta myeloid leukemia . A ranar 7 ga Fabrairu, 2007, an yi masa tiyatar da aka sani da dashen ƙwayoyin halitta na hematopoietic don magance cutar sankarar bargo (wanda ƙungiyar likitoci a Berlin, Jamus, ciki har da Gero Hütter suka yi). Daga 60 Daidai da masu ba da gudummawa, sun zaɓi mai ba da gudummawa mai suna [CCR5]-Δ32, mutum mai kwafin kwayoyin halitta guda biyu na wani nau'in mai karɓar saman tantanin halitta mai wuya. Wannan siffa ta kwayoyin halitta tana ba da juriya ga kamuwa da cutar HIV ta hanyar toshe hanyar da kwayar cutar HIV ke bi zuwa ga kwayar halitta. Kusan mutum ɗaya cikin 1,000 na asalin Turai suna da wannan maye gurbi, amma ya fi wuya a wasu al'ummomi. An sake yin dashen bayan shekara guda bayan sake kamuwa da cutar sankarar jini . Tsawon shekaru uku bayan dashen farko, kuma duk da dakatar da maganin hana kamuwa da cutar, masu bincike ba su iya gano cutar HIV a cikin jinin Brown ko a cikin wasu gwaje-gwajen biopsy ba. ^[5] Matakan ƙwayoyin rigakafi masu alaƙa da HIV a cikin jinin Timothy Brown suma sun ragu, wanda ke nuna cewa an cire kwayar cutar HIV mai aiki daga jikinsa. Duk da haka, masana kimiyya da ke nazarin lamarinsa sun yi gargaɗin cewa wannan sassaucin kamuwa da cutar HIV abu ne da ba a saba gani ba. ^[6]

Brown, "marasa lafiya a Berlin", ya sha wahala daga matsalolin dashen dashen mai tsanani, cututtukan dashen dashen dashen da kuma cutar leukoencephalopathy, wanda hakan ya sa masu bincike suka yanke shawarar cewa bai kamata a yi wa waɗanda ke ɗauke da cutar HIV tiyata ba, koda kuwa an sami isassun masu ba da gudummawa masu dacewa. ^{[7] [8]}

Shekaru goma sha ɗaya bayan haka, a wannan taron, an sanar da cewa da alama an warkar da wani mutum na biyu. An yi masa lakabi da "Majinyacin London", wanda daga baya ya bayyana kansa a matsayin Adam Castillejo . An kuma yi masa dashen ƙashi don magance ciwon daji ( Hodgkin's lymphoma ) amma an ba shi magungunan rage ƙarfin garkuwar jiki . Mai bayarwa da aka zaɓa shi ma yana ɗauke da maye gurbin CCR5-Δ32 . ^[4]

Ya zuwa shekarar 2017, wasu mutane shida kuma sun bayyana cewa an wanke su daga cutar HIV bayan sun kamu da cutar graft-versus-host; ɗaya daga cikinsu ne kawai ya sami ƙwayoyin halittar CCR5 masu canzawa, wanda hakan ya sa masu bincike suka yanke hukuncin cewa idan wanda aka yi wa dashen yana da cutar graft-versus-host, ƙwayoyin halittar da aka yi wa dashen na iya kashe ƙwayoyin garkuwar jiki masu ɗauke da cutar HIV. [1]

A watan Yulin 2012, Brown ya sanar da kafa gidauniyar Timothy Ray Brown a Washington, DC, wata gidauniya da aka sadaukar domin yaki da cutar kanjamau. ^{[9] [10]}

A watan Satumba na 2020, Brown ya bayyana cewa cutar sankarar bargo da ta haifar da maganin da aka yi masa a tarihi ta dawo a shekarar 2019 kuma yana fama da rashin lafiya mai tsanani. Brown ya shiga kulawar marasa lafiya a Palm Springs, California, inda daga baya ya mutu a ranar 29 ga Satumba, 2020. ^[11] Yana da shekaru 54.

• Majinyacin Berlin (1998)
• Adam Castillejo
• Stephen Crohn
• Juriyar Halitta ga HIV
• Mai ba da gudummawa na dogon lokaci
• Binciken Kanjamau/AIDS

1. 1 2 Mary Engel (February 20, 2019). "Timothy Ray Brown: The accidental AIDS icon". Fred Hutch. Archived from the original on October 16, 2018. Retrieved March 4, 2015.
2. ↑ Trudy Ring (September 7, 2012). "Is Anyone Immune to HIV?". HIVPlusMag. Archived from the original on March 9, 2016. Retrieved January 20, 2015.
3. 1 2 Timothy Ray Brown (January 12, 2015). "I am the Berlin patient: a personal reflection". AIDS Research and Human Retroviruses. 31 (1): 2–3. doi:10.1089/aid.2014.0224. PMC 4287108. PMID 25328084.
4. 1 2 "berlin patient.pdf" (PDF). Dropbox. Archived (PDF) from the original on September 30, 2020. Retrieved May 8, 2020.
5. ↑ Allers, K.; Hutter, G.; Hofmann, J.; Loddenkemper, C.; Rieger, K.; Thiel, E.; Schneider, T. (2010). "Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation". Blood. 117 (10): 2791–2799. doi:10.1182/blood-2010-09-309591. PMID 21148083.
6. ↑ "Web Exclusives : Transplanting Hope: Stem Cell Experiment Raises Eyebrows at CROI - by David Evans". Archived from the original on January 26, 2016. Retrieved January 21, 2015.
7. ↑ Levy JA (2009). "Not an HIV Cure, but Encouraging New Directions". N Engl J Med. 360 (7): 724–725. doi:10.1056/NEJMe0810248. PMID 19213687. Archived from the original on February 15, 2009. Retrieved March 31, 2009.
8. ↑ Lunzen, J.; Fehse, B.; Hauber, J. (2011). "Gene Therapy Strategies: Can We Eradicate HIV?". Current HIV/AIDS Reports. 8 (2): 78–84. doi:10.1007/s11904-011-0073-9. PMID 21331536. S2CID 43463970.
9. ↑ "Man "cured" of AIDS: Timothy Ray Brown". CBSNews. July 24, 2012. Archived from the original on June 12, 2018. Retrieved January 20, 2015.
10. ↑ "Miraculous Activist". The Scientist Magazine®. Archived from the original on August 9, 2020. Retrieved May 8, 2020.
11. ↑ Marilynn Marchione (September 25, 2020). "1st man cured of HIV infection now has terminal cancer". ABC News. Archived from the original on September 30, 2020. Retrieved September 25, 2020.; Mark S. King (September 25, 2020). "As Timothy Ray Brown faces death, a great love endures". Retrieved September 25, 2020.; "'The Berlin Patient': First person ever cured from HIV infection dies of cancer" (in Turanci). www.abc.net.au. September 30, 2020. Archived from the original on September 30, 2020. Retrieved September 30, 2020.