DEC2

BHLHE41
식별자
다른 이름	BHLHE41, DEC2, SHARP1, BHLHe41, HDEC2, SHARP-1, BHLHB3, Basic Helix-Loop-Helix Family Member E41, Basic Helix-Loop-Helix Family, Member E41, Class E Basic Helix-Loop-Helix Protein 41, Class B Basic Helix-Loop-Helix Protein 3, Basic Helix-Loop-Helix Domain Containing, Class B, 3, Differentially Expressed In Chondrocytes 2, Differentially Expressed In Chondrocytes Protein 2, Enhancer-Of-Split And Hairy-Related Protein 1, FNSS1
외부 ID	OMIM: 606200 MGI: 1930704 HomoloGene: 137401 GeneCards: BHLHE41
유전자 위치 (인간)
염색체	12번 염색체
끝	26,125,037 bp
유전자 위치 (쥐)
염색체	6번 염색체 (쥐)
끝	145,811,284 bp
RNA 발현 패턴
	최상위 발현
	오른자궁관; ; 미주신경 아래신경절; ; 아킬레스건; ; 시신경; ; subthalamic nucleus; ; 척수; ; C1 segment; ; 뇌량; ; pars reticulata; ; external globus pallidus;
	최상위 발현
	neural layer of retina; ; muscle of thigh; ; 수정란; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; 골격근 조직; ; 심실중격; ; 입술;
	추가 참조 발현 데이터
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	DNA 결합; protein dimerization activity; protein homodimerization activity; MRF binding; transcription corepressor activity; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; 단백질 결합; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
세포 성분	세포핵;
생물학적 과정	세포 분화; DNA를 주형으로 한 전사의 조절; rhythmic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; DNA를 주형으로 한 전사; negative regulation of myotube differentiation; animal organ morphogenesis; 세포 증식; negative regulation of transcription, DNA-templated; 일주기 생체 리듬; somitogenesis; Notch signaling pathway; regulation of neurogenesis; anterior/posterior pattern specification;
	출처: Amigo / QuickGO
동원체
	79365
	79362
	ENSG00000123095
	ENSMUSG00000030256
	Q9C0J9
	Q99PV5
	NM_030762
	NM_001271768; NM_024469
	NP_110389
	NP_001258697; NP_077789
	위키데이터
인간 보기/편집	쥐 보기/편집

BHLHE41(Basic helix-loop-helix family, member e41)은 인간과 생쥐의 다양한 조직에서 bHLH(basic helix-loop-helix) 전사인자(transcription factor,TF) 억제 단백질을 암호화하는 유전자이다.^[5]^[6]^[7]^[8] DEC2, hDEC2 및 SHARP1이라고도하며 이전에는 BHLHB3(basic helix-loop-helix domain containing, class B, 3)으로 알려져있었다.^[9] BHLHE41은 수면량에 영향을 미치는 일주기 분자 메커니즘에서의 역할뿐만 아니라 면역 기능에서의 역할 및 체액 면역과 관련된 보조 T세포(Helper T cell)의 T보조2형 세포(T helper type 2 cell ) 계통의 성숙으로 알려져있다.^[10]^[11]

생체시계 유전자

이러한 생체시계와 관련된 유전자로 밝혀진 것으로는 Period, NCX2, CLOCK, TP53 등이 있다.

같이 보기

참고

1 2 3 GRCh38: Ensembl release 89: ENSG00000123095 - 앙상블, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030256 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “BHLHE41 basic helix-loop-helix family, member e41 [ Homo sapiens (human) ]”. National Center for Biotechnology Information.
↑ “Bhlhe41 basic helix-loop-helix family, member e41 [ Mus musculus (house mouse) ]”. NCBI.
↑ Stevens JD, Roalson EH, Skinner MK (November 2008). “Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation”. 《Differentiation; Research in Biological Diversity》 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.
↑ “Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3”.
↑ “Basic Helix-Loop-Helix Family, Member E41”. Weizmann Institute of Science. 2014년 5월 28일에 원본 문서에서 보존된 문서. 2014년 5월 27일에 확인함.
↑ Kurien PA, Chong SY, Ptáček LJ, Fu YH (October 2013). “Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function”. 《Current Opinion in Neurobiology》 23 (5): 873–9. doi:10.1016/j.conb.2013.04.014. PMC 3766463. PMID 23702243.
↑ Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (December 2009). “Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment” (영어). 《Nature Immunology》 10 (12): 1260–6. doi:10.1038/ni.1821. PMC 2784129. PMID 19881507.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123095 - 앙상블, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030256 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[NCBI_human-5] “BHLHE41 basic helix-loop-helix family, member e41 [ Homo sapiens (human) ]”. National Center for Biotechnology Information.

[NCBI_mouse-6] “Bhlhe41 basic helix-loop-helix family, member e41 [ Mus musculus (house mouse) ]”. NCBI.

[pmid18557763-7] Stevens JD, Roalson EH, Skinner MK (November 2008). “Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation”. 《Differentiation; Research in Biological Diversity》 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.

[entrez-8] “Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3”.

[Weizmann-9] “Basic Helix-Loop-Helix Family, Member E41”. Weizmann Institute of Science. 2014년 5월 28일에 원본 문서에서 보존된 문서. 2014년 5월 27일에 확인함.

[Kurien_2013-10] Kurien PA, Chong SY, Ptáček LJ, Fu YH (October 2013). “Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function”. 《Current Opinion in Neurobiology》 23 (5): 873–9. doi:10.1016/j.conb.2013.04.014. PMC 3766463. PMID 23702243.

[11] Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (December 2009). “Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment” (영어). 《Nature Immunology》 10 (12): 1260–6. doi:10.1038/ni.1821. PMC 2784129. PMID 19881507.

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