Memantine

Memantine
Clinical data
Trade names	Axura, Ebixa, Namenda, others
AHFS/Drugs.com	Monograph
MedlinePlus	a604006
[[Regulation of therapeutic goods \|Endrika:Engvar data]]	EU EMA: by INN; US DailyMed: Memantine; US FDA: Namenda;
Pregnancy; category	AU: B2;
Routes of; administration	By mouth
Drug class	NMDA receptor inhibitor
Sata ara-dalàna
Sata ara-dalàna	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	~100%
Metabolism	Liver (<10%)
Elimination half-life	60–100 hours
Excretion	Kidney
Identifiers
	IUPAC name 3,5-dimethyltricyclo[3.3.1.13,7]decan-1amine; or; 3,5-dimethyladamantan-1-amine ;
Angon-drakitra simika sy ara-batana
Raikipohy	C12H21N
Molar mass	179307 g·mol−1
Modely 3D (JSmol)	Interactive image;
	SMILES NC12CC3(CC(C1)(CC(C2)C3)C)C ;
	InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 ; Key:BUGYDGFZZOZRHP-UHFFFAOYSA-N ;
	(verify)

Memantine dia fanafody ampiasaina amin’ny fitsaboana ny aretin’i Alzheimer antonony ka hatramin’ny mafy. [1] [2] Tsy dia ampiasaina loatra izy io raha oharina amin’ny fanafody mpanakana ny acetylcholinesterase toy ny donepezil. [2] Tokony hotohizana ny fitsaboana raha hita fa mahomby. [2] Atelina amin’ny vava izy io. [1]

Anisan'ny voka-dratsiny mahazatra ny aretin'andoha, fitohanana, fahatsapana rendremana ary fanina.^[2]^[3] Mety ahitana fivontosan-dra, aretin-tsaina, ary tsy fahombiazan'ny fo ny voka-dratsiny mafy.^[3] Inoana fa miasa amin'ny fanakanana ireo mpandray NMDA izy io.^[2]

Nekena ho ampiasaina ara-pitsaboana tany Etazonia tamin'ny taona 2003 ny Memantine.^[2] Azo alaina amin'ny endrika fanafody tsy misy fangarony izy io.^[3] Mitentina 1.60 GBP eo ho eo ho an'ny NHS ny famatsiana iray volana any Royaume-Uni tamin'ny taona 2019.^[3] Any Etazonia, ny vidin'ity vola ity amin'ny ambongadiny dia eo amin'ny 5.50 dolara amerikana eo ho eo.^[4] Tamin'ny taona 2017, io no fanafody faha-149 be mpampiasa indrindra any Etazonia, miaraka amin'ny fanafody mihoatra ny efatra tapitrisa.^[5]^[6]

References

↑ "International brands for memantine". Drugs.com. Archived from the original on 25 April 2019. Retrieved 7 August 2017. Endrika:Webarchive
1 2 3 4 "Memantine Hydrochloride Monograph for Professionals". Drugs.com (in Anglisy). American Society of Health-System Pharmacists. Archived from the original on 25 April 2019. Retrieved 3 March 2019.
1 2 3 4 (2018) British national formulary : BNF 76, 76, Pharmaceutical Press, 303–304.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in Anglisy). Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Memantine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[brands-1] "International brands for memantine". Drugs.com. Archived from the original on 25 April 2019. Retrieved 7 August 2017. Endrika:Webarchive

[AHFS2019-2] 1 2 3 4 "Memantine Hydrochloride Monograph for Professionals". Drugs.com (in Anglisy). American Society of Health-System Pharmacists. Archived from the original on 25 April 2019. Retrieved 3 March 2019.

[BNF76-3] 1 2 3 4 (2018) British national formulary : BNF 76, 76, Pharmaceutical Press, 303–304.

[NADAC2019-4] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in Anglisy). Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[ref-5] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-6] "Memantine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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