Acenokumarol

Acenokumarol
Klinički podaci
Prodajno ime	Ascumar, Mini-sintrom, Neositron, Sincoumar
Drugs.com	Monografija
Način primene	Oralno
Identifikatori
CAS broj	152-72-7
ATC kod	B01AA07 (WHO)
PubChem	CID 9052
DrugBank	DB01418
ChemSpider	10443441
ChEBI	CHEBI:53766
ChEMBL	CHEMBL397420

Acenokumarol je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 353,325 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	1
Broj rotacionih veza	5
Particioni koeficijent^[8] (ALogP)	2,7
Rastvorljivost^[9] (logS, log(mol/L))	-4,9
Polarna površina^[10] (PSA, Å²)	109,4

Reference

^ Cesar JM, Garcia-Avello A, Navarro JL, Herraez MV: Aging and oral anticoagulant therapy using acenocoumarol. Cesar, J. M.; García-Avello, A.; Navarro, J. L.; Herraez, M. V. (2004 Oct). „Aging and oral anticoagulant therapy using acenocoumarol”. Blood Coagul Fibrinolysis. 15 (8): 673—6. PMID 15613922. doi:10.1097/00001721-200412000-00007. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Lengyel M: [Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?] Lengyel, M.; SPORTIF-III Altanulmány Vizsgálói (2004 Dec 26). „Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?”. Orv Hetil. 145 (52): 2619—21. PMID 15724697. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Ufer M: Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Ufer, M. (2005). „Comparative pharmacokinetics of vitamin K antagonists: Warfarin, phenprocoumon and acenocoumarol”. Clin Pharmacokinet. 44 (12): 1227—46. PMID 16372822. doi:10.2165/00003088-200544120-00003.
^ Montes R, Ruiz de Gaona E, Martinez-Gonzalez MA, Alberca I, Hermida J: The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Montes, R.; Ruiz De Gaona, E.; Martínez-González, M. A.; Alberca, I.; Hermida, J. (2006 Apr). „The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients”. Br J Haematol. 133 (2): 183—7. PMID 16611310. doi:10.1111/j.1365-2141.2006.06007.x. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Girard P, Nony P, Erhardtsen E, Delair S, Ffrench P, Dechavanne M, Boissel JP: Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol. Girard, P.; Nony, P.; Erhardtsen, E.; Delair, S.; Ffrench, P.; Dechavanne, M.; Boissel, J. P. (1998 Jul). „Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol”. Thromb Haemost. 80 (1): 109—13. PMID 9684795. doi:10.1055/s-0037-1615148. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Acenocoumarol Архивирано на веб-сајту Wayback Machine (15. април 2014)

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[1] Cesar JM, Garcia-Avello A, Navarro JL, Herraez MV: Aging and oral anticoagulant therapy using acenocoumarol. Cesar, J. M.; García-Avello, A.; Navarro, J. L.; Herraez, M. V. (2004 Oct). „Aging and oral anticoagulant therapy using acenocoumarol”. Blood Coagul Fibrinolysis. 15 (8): 673—6. PMID 15613922. doi:10.1097/00001721-200412000-00007. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Lengyel M: [Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?] Lengyel, M.; SPORTIF-III Altanulmány Vizsgálói (2004 Dec 26). „Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?”. Orv Hetil. 145 (52): 2619—21. PMID 15724697. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Ufer M: Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Ufer, M. (2005). „Comparative pharmacokinetics of vitamin K antagonists: Warfarin, phenprocoumon and acenocoumarol”. Clin Pharmacokinet. 44 (12): 1227—46. PMID 16372822. doi:10.2165/00003088-200544120-00003.

[4] Montes R, Ruiz de Gaona E, Martinez-Gonzalez MA, Alberca I, Hermida J: The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Montes, R.; Ruiz De Gaona, E.; Martínez-González, M. A.; Alberca, I.; Hermida, J. (2006 Apr). „The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients”. Br J Haematol. 133 (2): 183—7. PMID 16611310. doi:10.1111/j.1365-2141.2006.06007.x. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Girard P, Nony P, Erhardtsen E, Delair S, Ffrench P, Dechavanne M, Boissel JP: Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol. Girard, P.; Nony, P.; Erhardtsen, E.; Delair, S.; Ffrench, P.; Dechavanne, M.; Boissel, J. P. (1998 Jul). „Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol”. Thromb Haemost. 80 (1): 109—13. PMID 9684795. doi:10.1055/s-0037-1615148. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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